pooled human liver microsomes (pooled male female Search Results


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Becton Dickinson pooled human liver microsome 15 donors
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rat and dog pooled liver microsomes - by Bioz Stars, 2026-09
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Sekisui XenoTech pooled cd-1 mouse liver microsomes at a concentration of 20 mg/ml
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Sekisui XenoTech pooled human liver microsomes potassium phosphate buffer, ph7.4
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Puracyp Inc human liver microsomes
In vitro metabolism of cocaine by pooled human, mouse, and rat liver <t>microsomes.</t> (A–C) Representative chromatogram of major phase I cocaine metabolites formed by MLM, RLM, and HLM, respectively. Ions within the 20 ppm range of theoretical accurate mass ([M+H]+) of cocaine (I) and its metabolites (200.1287, 290.1392, 306.1341, 320.1498, and 336.1447 m/z) were extracted and labeled in the chromatograms. The ion intensity of the most abundant metabolites was set arbitrarily as 100%. Major phase I metabolites are labeled. The chemical identities of these metabolites are presented in the Table 1. One unknown metabolite is labeled as “UK”. (D) A comparison of phase I cocaine metabolites formed by microsomal incubations (n = 3). Relative abundance of individual cocaine metabolite formed by MLM, RLM, and HLM was represented as a relative peak area (area % ± S.D.) by calculating its percentage in the total peak area of all detected phase I cocaine metabolites.
Human Liver Microsomes, supplied by Puracyp Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
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Becton Dickinson pooled human or mouse liver microsomes
In vitro metabolism of cocaine by pooled human, mouse, and rat liver <t>microsomes.</t> (A–C) Representative chromatogram of major phase I cocaine metabolites formed by MLM, RLM, and HLM, respectively. Ions within the 20 ppm range of theoretical accurate mass ([M+H]+) of cocaine (I) and its metabolites (200.1287, 290.1392, 306.1341, 320.1498, and 336.1447 m/z) were extracted and labeled in the chromatograms. The ion intensity of the most abundant metabolites was set arbitrarily as 100%. Major phase I metabolites are labeled. The chemical identities of these metabolites are presented in the Table 1. One unknown metabolite is labeled as “UK”. (D) A comparison of phase I cocaine metabolites formed by microsomal incubations (n = 3). Relative abundance of individual cocaine metabolite formed by MLM, RLM, and HLM was represented as a relative peak area (area % ± S.D.) by calculating its percentage in the total peak area of all detected phase I cocaine metabolites.
Pooled Human Or Mouse Liver Microsomes, supplied by Becton Dickinson, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Becton Dickinson pooled human liver microsomes (phlm, 20 mg microsomal protein/ml, 400 pmol total cyp/mg protein)
In vitro metabolism of cocaine by pooled human, mouse, and rat liver <t>microsomes.</t> (A–C) Representative chromatogram of major phase I cocaine metabolites formed by MLM, RLM, and HLM, respectively. Ions within the 20 ppm range of theoretical accurate mass ([M+H]+) of cocaine (I) and its metabolites (200.1287, 290.1392, 306.1341, 320.1498, and 336.1447 m/z) were extracted and labeled in the chromatograms. The ion intensity of the most abundant metabolites was set arbitrarily as 100%. Major phase I metabolites are labeled. The chemical identities of these metabolites are presented in the Table 1. One unknown metabolite is labeled as “UK”. (D) A comparison of phase I cocaine metabolites formed by microsomal incubations (n = 3). Relative abundance of individual cocaine metabolite formed by MLM, RLM, and HLM was represented as a relative peak area (area % ± S.D.) by calculating its percentage in the total peak area of all detected phase I cocaine metabolites.
Pooled Human Liver Microsomes (Phlm, 20 Mg Microsomal Protein/Ml, 400 Pmol Total Cyp/Mg Protein), supplied by Becton Dickinson, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
pooled human liver microsomes (phlm, 20 mg microsomal protein/ml, 400 pmol total cyp/mg protein) - by Bioz Stars, 2026-09
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In vitro metabolism of cocaine by pooled human, mouse, and rat liver microsomes. (A–C) Representative chromatogram of major phase I cocaine metabolites formed by MLM, RLM, and HLM, respectively. Ions within the 20 ppm range of theoretical accurate mass ([M+H]+) of cocaine (I) and its metabolites (200.1287, 290.1392, 306.1341, 320.1498, and 336.1447 m/z) were extracted and labeled in the chromatograms. The ion intensity of the most abundant metabolites was set arbitrarily as 100%. Major phase I metabolites are labeled. The chemical identities of these metabolites are presented in the Table 1. One unknown metabolite is labeled as “UK”. (D) A comparison of phase I cocaine metabolites formed by microsomal incubations (n = 3). Relative abundance of individual cocaine metabolite formed by MLM, RLM, and HLM was represented as a relative peak area (area % ± S.D.) by calculating its percentage in the total peak area of all detected phase I cocaine metabolites.

Journal: Drug Metabolism and Disposition

Article Title: Characterization of Differential Cocaine Metabolism in Mouse and Rat through Metabolomics-Guided Metabolite Profiling

doi: 10.1124/dmd.112.048678

Figure Lengend Snippet: In vitro metabolism of cocaine by pooled human, mouse, and rat liver microsomes. (A–C) Representative chromatogram of major phase I cocaine metabolites formed by MLM, RLM, and HLM, respectively. Ions within the 20 ppm range of theoretical accurate mass ([M+H]+) of cocaine (I) and its metabolites (200.1287, 290.1392, 306.1341, 320.1498, and 336.1447 m/z) were extracted and labeled in the chromatograms. The ion intensity of the most abundant metabolites was set arbitrarily as 100%. Major phase I metabolites are labeled. The chemical identities of these metabolites are presented in the Table 1. One unknown metabolite is labeled as “UK”. (D) A comparison of phase I cocaine metabolites formed by microsomal incubations (n = 3). Relative abundance of individual cocaine metabolite formed by MLM, RLM, and HLM was represented as a relative peak area (area % ± S.D.) by calculating its percentage in the total peak area of all detected phase I cocaine metabolites.

Article Snippet: Pooled human liver microsomes were purchased from Puracyp (Carlsbad, CA).

Techniques: In Vitro, Labeling, Comparison